Following this Court's decision s in United States v. Booker , 543 U.S. 220 (2005), and Gall v. United States , 552 U.S. 38 (2007), whether a district court imposes a substantively unreasonable sentence when it upward varies from the sentencing guidelines range but affords no real weight to a defendant's mitigating history and characteristics under 18 U.S.C. § 3553(a)(1) ?

Whether a district court imposes a substantively unreasonable sentence when it upward varies from the sentencing guidelines range but affords no real weight to a defendant's mitigating history and characteristics under 18 U.S.C. § 3553(a)(1)